Genetic Link Between MMP1 Polymorphism and Lumbar Disc Disease
Author Information
Author(s): Song You-Qiang, Ho Daniel WH, Karppinen Jaro, Kao Patrick YP, Fan Bao-Jian, Luk Keith DK, Yip Shea-Ping, Leong John CY, Cheah Kathryn SE, Sham Pak, Chan Danny, Cheung Kenneth MC
Primary Institution: University of Hong Kong
Hypothesis
Is there an association between the -1607 promoter polymorphism of MMP1 and lumbar disc disease (DDD) in Southern Chinese individuals?
Conclusion
Individuals with the D allele for the -1607 polymorphism of MMP1 are about 1.5 times more susceptible to develop DDD compared to those with only the G allele.
Supporting Evidence
- The D allele was significantly associated with DDD (p=0.027, OR=1.41).
- Genotypic association on the presence of D allele was also significant (p=0.046, OR=1.50).
- Age stratification showed significant associations in individuals over 40 years.
Takeaway
This study found that a specific genetic change makes people more likely to have back problems as they get older.
Methodology
The study involved genotyping Southern Chinese volunteers aged 18-55 and assessing DDD through MRI.
Limitations
The study did not stratify results by gender due to no significant differences in disease predisposition.
Participant Demographics
691 individuals, 266 males and 425 females, aged 18-55.
Statistical Information
P-Value
0.027
Confidence Interval
1.04–1.90
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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