Bifidobacterium longum JBLC-141 Helps Protect the Gut from High-Altitude Stress
Author Information
Author(s): Li Xiang-Yang, Shang Jin, Wang Xiao-Juan, Ma Hui-Ping, Ren Long-Fei, Zhang Lei
Primary Institution: The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China
Hypothesis
B. longum alleviates the intestinal barrier damage induced by plateau hypobaric hypoxia by protecting the intestinal barrier and regulating the intestinal flora.
Conclusion
B. longum JBLC-141 can counteract intestinal oxidative stress, inhibit inflammatory responses, improve intestinal permeability and apoptosis, and upregulate the expression of intestinal tight junction proteins.
Supporting Evidence
- B. longum JBLC-141 mitigates the effects of plateau low-pressure hypoxia on the rat intestinal barrier.
- B. longum JBLC-141 activates the KEAP1/NRF2 pathway, alleviating oxidative stress injury.
- B. longum JBLC-141 reduces intestinal permeability and repairs barrier histological damage.
- B. longum JBLC-141 increases the relative abundance of beneficial bacteria in the gut.
Takeaway
This study shows that a type of good bacteria called Bifidobacterium longum can help protect the gut when people go to high places where there is less oxygen.
Methodology
An in vivo model was established by exposing rats to a simulated low-pressure hypoxic plateau environment, followed by supplementation with B. longum JBLC-141.
Limitations
The study's findings are only relevant to the specific conditions tested and further research is needed to clarify the mechanisms involved.
Participant Demographics
32 male Sprague–Dawley rats, 6 weeks old.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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