Quantitative Expression Profile of Distinct Functional Regions in the Adult Mouse Brain
Author Information
Author(s): Kasukawa Takeya, Masumoto Koh-hei, Nikaido Itoshi, Nagano Mamoru, Uno Kenichiro D., Tsujino Kaori, Hanashima Carina, Shigeyoshi Yasufumi, Ueda Hiroki R.
Primary Institution: RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
Hypothesis
To find quantitative differences of expression among various brain regions in the adult mouse.
Conclusion
The study identified 8,159 multi-state genes and developed an integrated database for exploring genome-wide expression in the adult mouse brain.
Supporting Evidence
- Identified 8,159 multi-state genes across 51 brain regions.
- Developed a publicly accessible database for mouse brain gene expression.
- Found 2,212 regional marker gene candidates for 44 small brain regions.
Takeaway
Scientists studied different parts of a mouse brain to see how genes work in each area, helping us understand brain functions better.
Methodology
The study used DNA-microarray technology to analyze gene expression in 51 distinct CNS regions sampled every 4 hours for 24 hours.
Potential Biases
Potential biases may arise from the limited number and size of samples used for the BrainStars dataset.
Limitations
Some prominent brain regions were not included in this analysis, and the study may not cover all developmental stages and conditions.
Participant Demographics
Balb/c male mice, 5 weeks postpartum.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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