Brazilian Propolis Extract Increases Lifetimes of Mice Infected with Influenza A Virus
Author Information
Author(s): Tomoaki Takemura, Tomohiko Urushisaki, Mayuko Fukuoka, Junji Hosokawa-Muto, Taketoshi Hata, Yumiko Okuda, Sachie Hori, Shigemi Tazawa, Yoko Araki, Kazuo Kuwata
Primary Institution: Gifu University
Hypothesis
Does Brazilian green propolis extract enhance survival and TRAIL expression in mice infected with the influenza A virus?
Conclusion
Brazilian green propolis extract and its component 3,4-dicaffeoylquinic acid significantly extend the lifetimes of mice infected with the influenza A virus by increasing TRAIL expression.
Supporting Evidence
- Propolis extracts significantly increased the survival rates of mice infected with the influenza virus.
- 3,4-dicaffeoylquinic acid showed a stronger effect than the propolis extract itself.
- TRAIL mRNA levels were significantly higher in treated mice compared to controls.
Takeaway
This study found that a natural substance from Brazilian propolis can help mice live longer after getting sick with the flu by boosting their immune response.
Methodology
Mice were treated with Brazilian green propolis extracts and their survival times and TRAIL mRNA expression were measured after infection with the influenza A virus.
Limitations
The study primarily focused on a specific strain of influenza and may not generalize to all strains.
Participant Demographics
Female BALB/c mice, 5 weeks old.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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