Platelet Function Tests and Stroke Prognosis
Author Information
Author(s): Ho Hsin-Ju, Wu Li-Ching, Chen Yu-Wei, Bhaskar Sonu M. M.
Primary Institution: Landseed International Hospital
Hypothesis
Can point-of-care platelet function measurements predict favorable outcomes in patients with acute ischemic stroke?
Conclusion
Changes in platelet function measurements may help predict favorable clinical outcomes in patients with acute ischemic stroke.
Supporting Evidence
- Serial PFA-100 measurements were associated with favorable outcomes at 1-month and 1-year follow-ups.
- A difference in CEPI closure time greater than 99 seconds was predictive of a favorable outcome.
- High baseline hemoglobin levels were significantly associated with favorable outcomes.
Takeaway
Doctors can check how well platelets work in stroke patients to see if they will recover well after treatment.
Methodology
A prospective cohort study was conducted on 212 AIS patients, measuring platelet function at baseline, week 2, and week 4 using PFA-100.
Potential Biases
Potential bias due to the exclusion of patients with prior antiplatelet use and the reliance on self-reported medication compliance.
Limitations
The study's findings may not be generalizable due to the small sample sizes in subgroups and the timing of platelet function tests.
Participant Demographics
Mean age of participants was 65.04 years, with a male predominance (63.68%) and prevalent vascular risk factors.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 2.318–60.669
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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