Leptin Levels and Obesity in Pre-Diabetic Saudis
Author Information
Author(s): Nasser M Al-Daghri, Omar S Al-Attas, Khalid Al-Rubeaan, Mehad Mohieldin, Mohammad Al-Katari, Alan F Jones, Sudhesh Kumar
Primary Institution: King Saud University, Riyadh, Saudi Arabia
Hypothesis
This study aims to determine and correlate leptin levels to anthropometric measures of obesity in pre-diabetic, type 2 diabetic, and normoglycaemic Saudis.
Conclusion
Leptin is associated with measures of adiposity, particularly hip circumference, in non-diabetic Saudi subjects, while higher leptin levels in diabetics and pre-diabetics are not related to differences in obesity measures.
Supporting Evidence
- Leptin levels in diabetic men were significantly higher than in normoglycaemic men.
- Pre-diabetic women had higher leptin levels than normoglycaemic women.
- Hip circumference was positively associated with log leptin after adjusting for BMI and gender.
Takeaway
This study found that people with pre-diabetes and diabetes have higher leptin levels than those without, but this doesn't mean they are more obese.
Methodology
308 adult Saudis participated, with anthropometric measurements taken and fasting blood samples analyzed for serum insulin and leptin concentrations.
Participant Demographics
308 adult Saudis, including healthy controls, pre-diabetics, and type 2 diabetics.
Statistical Information
P-Value
p = 0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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