Ganglioside composition and histology of a spontaneous metastatic brain tumour in the VM mouse
2001
Study of Gangliosides in a Brain Tumor in VM Mice
Sample size: 9
publication
Author Information
Author(s): El-Abbadi M, Seyfried T N, Yates A J, Orosz C, Lee M C
Primary Institution: Department of Biology, Boston College
Hypothesis
Glycosphingolipid abnormalities are implicated in tumor malignancy and metastasis.
Conclusion
The study found distinct differences in ganglioside composition between subcutaneously grown tumors and cultured tumor cells.
Supporting Evidence
- The tumor arose spontaneously and metastasizes to several organs.
- The total ganglioside sialic acid content of the subcutaneously grown tumor was low.
- The ganglioside content of the cultured VM tumor cells was high and consisted almost exclusively of N-acetylneuraminic acid.
Takeaway
This study looked at a type of brain tumor in mice and found that the fats in the tumor cells are different from those in the tumors that grow in the body.
Methodology
Histology and ganglioside composition were examined in a natural brain tumor of the VM mouse strain.
Participant Demographics
VM mouse strain
Digital Object Identifier (DOI)
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