Effects of Low-Level Direct Current Therapy on Tumors
Author Information
Author(s): D.T. Griffin, N.J.F. Dodd, J.V. Moore, B.R. Pullan, T.V. Taylor
Primary Institution: Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust
Hypothesis
Can low-level direct current therapy effectively destroy tumor tissue and induce tumor regression?
Conclusion
Low-level direct current therapy can significantly reduce tumor volume, with anodic treatment being more effective than cathodic treatment.
Supporting Evidence
- Anodic treatment resulted in greater tumor regression compared to cathodic treatment.
- A direct correlation was found between the charge passed and the volume of tumor regression.
- Mortality was observed at higher charges, indicating a limit to the treatment's safety.
Takeaway
This study shows that using a small electric current can help shrink tumors in mice, and using the positive side of the current works better than the negative side.
Methodology
Mice with tumors were treated with direct current therapy, and tumor sizes were measured to assess the effects of different charges and polarities.
Limitations
The study was limited by the mortality of animals at higher charges, which restricted the examination of dose-response relationships.
Participant Demographics
Male B6DF21 mice, 6-8 weeks old, approximately 25 g in weight.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
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