Induction of Labour vs. Expectant Monitoring for Gestational Hypertension
Author Information
Author(s): Josje Langenveld, Kim Broekhuijsen, Gert-Jan van Baaren, Maria G van Pampus, Anton H van Kaam, Henk Groen, Martina Porath, Martijn A Oudijk, Kitty W Bloemenkamp, Christianne J de Groot, Erik van Beek, Marloes E van Huizen, Herman P Oosterbaan, Christine Willekes, Ella J Wijnen-Duvekot, Maureen T M Franssen, Denise A M Perquin, Jan M J Sporken, Mallory D Woiski, Henk A Bremer, Dimitri N M Papatsonis, Jozien T J Brons, Mesrure Kaplan, Bas W A Nij Bijvanck, Ben-Willen J Mol
Primary Institution: Maastricht University Medical Centre
Hypothesis
Induction of labour will reduce maternal morbidity and mortality, but at the cost of increased neonatal morbidity.
Conclusion
The trial will provide evidence on whether induction of labour in women with hypertensive disorders in the late pre-term period is effective in preventing severe maternal complications without compromising neonatal health.
Supporting Evidence
- Induction of labour reduces the risk of severe maternal complications.
- Late pre-term infants have higher morbidity compared to term infants.
- The study aims to clarify the management of hypertensive disorders in late pre-term pregnancies.
Takeaway
This study is trying to find out if inducing labor early for pregnant women with high blood pressure is better than waiting, to keep both moms and babies healthy.
Methodology
A multicentre, open-label randomised controlled trial comparing induction of labour with expectant monitoring in women with gestational hypertension or mild pre-eclampsia at 34-37 weeks of gestation.
Potential Biases
Potential bias due to the open-label design and the inability to blind participants and healthcare providers.
Limitations
The study may not account for all variations in clinical practice and patient demographics across different centers.
Participant Demographics
Pregnant women aged 18 and older with gestational hypertension, mild pre-eclampsia, or deteriorating chronic hypertension between 34+0 and 36+6 weeks of gestation.
Statistical Information
P-Value
0.05
Confidence Interval
95% CI 0.55 - 1.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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