Possible Roles of Ectophosphatases in Host-Parasite Interactions
2011
Roles of Ectophosphatases in Host-Parasite Interactions
publication
Evidence: moderate
Author Information
Author(s): Marta T. Gomes, Angela H. Lopes, José Roberto Meyer-Fernandes
Primary Institution: Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro
Hypothesis
What roles do ectophosphatases play in host-parasite interactions?
Conclusion
Ectophosphatases are important for the survival of pathogens in hostile environments and help them evade host immune responses.
Supporting Evidence
- Ectophosphatases are found in many pathogenic organisms, including bacteria, protozoa, and fungi.
- These enzymes help pathogens survive by hydrolyzing phosphate groups from proteins.
- Ectophosphatases may play a role in cell differentiation and infection of host cells.
- Some ectophosphatases are linked to the ability of pathogens to evade the immune response.
Takeaway
Ectophosphatases are special proteins that help germs stick to and survive in our bodies, making it easier for them to cause infections.
Methodology
The review summarizes findings from various studies on ectophosphatases in protozoa and fungi.
Limitations
The physiological roles of ectophosphatases in many pathogens are not well established.
Digital Object Identifier (DOI)
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