Inflammation and Kidney Function in Stroke Outcomes
Author Information
Author(s): Zhichao Huang, Xiaoyue Zhu, Xiuman Xu, Yi Wang, Yafang Zhu, Dongqin Chen, Yongjun Cao, Xia Zhang
Primary Institution: Second Affiliated Hospital of Soochow University
Hypothesis
Can renal function status and inflammatory biomarkers predict in-hospital outcomes in acute ischemic stroke patients treated with intravenous thrombolysis?
Conclusion
Combining renal function status and inflammatory biomarkers within 4.5 hours after onset could better predict in-hospital outcomes of acute ischemic stroke patients treated with intravenous thrombolysis.
Supporting Evidence
- Patients with elevated WBC or CRP levels combined with low eGFR had the highest risk of post-stroke pneumonia.
- The addition of inflammatory biomarkers significantly improved risk prediction for clinical outcomes.
- Patients in the WBC↑/eGFR↓ and CRP↑/eGFR↓ groups had the worst short-term functional prognosis.
- Inflammation and renal dysfunction coexist in acute ischemic stroke patients.
Takeaway
Doctors can better predict how well stroke patients will do in the hospital by looking at their kidney function and inflammation levels.
Methodology
The study retrospectively analyzed 409 acute ischemic stroke patients treated with intravenous thrombolysis, classifying them based on inflammatory biomarkers and renal function.
Potential Biases
Potential bias due to the retrospective nature of the study and exclusion criteria that may limit generalizability.
Limitations
The study may overestimate CKD prevalence as eGFR was based on baseline creatinine at the time of vascular events, and only one measurement was taken for each parameter.
Participant Demographics
Patients included were acute ischemic stroke patients treated with intravenous thrombolysis, with a mean age of approximately 66.6 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 1.67–15.87 for post-stroke pneumonia; 95% CI 2.25–15.74 for poor functional outcome.
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website