Reduction in membranous expression of β-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer
1999
β-catenin and E-cadherin Expression in Gastric Cancer
Sample size: 40
publication
Evidence: moderate
Author Information
Author(s): Ramesh S, Nash J, McCulloch P G
Primary Institution: University of Liverpool
Hypothesis
Which type of expression abnormalities for E-cadherin, β-catenin and α-catenin correlate with clinico-pathological features and survival in gastric cancer?
Conclusion
Reduced membranous expression of β-catenin predicts poor prognosis in gastric cancer.
Supporting Evidence
- Reduced membranous expression of β-catenin occurred in 83% of diffuse tumours.
- Reduced membranous expression of β-catenin was associated with poor differentiation.
- Reduced membranous expression of β-catenin was associated with short survival.
- Reduced E-cadherin membrane expression was associated with lymph node metastasis.
Takeaway
This study found that low levels of a protein called β-catenin on the surface of cancer cells can mean a person with gastric cancer might not live as long.
Methodology
Immunoperoxidase staining of paraffin-embedded sections from gastric cancers was performed for E-cadherin, α- and β-catenins.
Statistical Information
P-Value
0.0014
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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