Antithrombin significantly influences platelet adhesion onto immobilized fibrinogen in an in-vitro system simulating low flow

2006

Antithrombin's Role in Platelet Adhesion

Sample size: 29 publication Evidence: moderate

Author Information

Author(s): Robert Loncar, Uwe Kalina, Volker Stoldt, Volker Thomas, Rüdiger E. Scharf, Aleksandar Vodovnik

Primary Institution: Heinrich Heine University Medical Center Duesseldorf, Germany

Antithrombin influences platelet adhesion onto immobilized fibrinogen in an in-vitro low flow system.

Antithrombin suppresses platelet adhesion onto immobilized fibrinogen under low flow conditions, which may have clinical implications.

Platelet adhesion increased significantly with lower antithrombin activity.
Antithrombin supplementation reduced platelet adhesion by 65%.
An inverse correlation was found between plasma antithrombin levels and platelet adhesion.

Antithrombin helps keep platelets from sticking together too much, which is important for preventing clots in the blood.

Platelets from 29 healthy donors were tested for adhesion to fibrinogen under different flow rates using a flow chamber.

Potential bias from the selection of healthy donors and exclusion criteria.

The study was limited to healthy donors and may not represent all populations.

29 healthy blood donors, mean age 44 ± 12 years, 21 men and 8 women.

p < 0.05

p<0.05

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