Mitochondrial recoupling in cancer therapy
2011
Mitochondrial recoupling: a novel therapeutic strategy for cancer?
publication
Author Information
Author(s): Baffy G, Derdak Z, Robson S C
Primary Institution: VA Boston Healthcare System and Brigham and Women's Hospital, Harvard Medical School
Hypothesis
Can inhibition of mitochondrial uncoupling proteins (UCPs) provide novel anti-cancer strategies?
Conclusion
Inhibition of UCPs may eliminate cancer cell responses that promote chemoresistance and metabolic reprogramming.
Supporting Evidence
- UCP2 is highly abundant in some cancers and may promote chemoresistance.
- Inhibition of UCP2 may improve responsiveness to conventional cancer drugs.
- UCP2 expression is linked to oxidative stress and neoplastic changes.
Takeaway
This study suggests that blocking certain proteins in cancer cells might help make them more sensitive to treatment.
Digital Object Identifier (DOI)
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