Antioxidant Activity of Lawsonia inermis Extracts Inhibits Chromium(VI)-Induced Cellular and DNA Toxicity
2011
Antioxidant Activity of Henna Extracts Against Chromium-Induced Toxicity
Sample size: 3
publication
Evidence: moderate
Author Information
Author(s): Gunjan Guha, Rajkumar V. Kumar, R. Ashok, Mathew Lazar
Primary Institution: VIT University
Hypothesis
The study aims to evaluate the effects of Lawsonia inermis extracts on chromium(VI)-induced oxidative toxicity.
Conclusion
Both aqueous and methanolic extracts of Lawsonia inermis can inhibit chromium(VI)-induced oxidative damage in cells and DNA.
Supporting Evidence
- The extracts showed significant potential in scavenging free radicals and inhibiting lipid peroxidation.
- DNA damage caused by chromium exposure was markedly inhibited by both extracts.
- Both extracts contained a high content of phenolic compounds correlated with their antioxidant potential.
Takeaway
Henna extracts can help protect cells from damage caused by a harmful metal called chromium.
Methodology
The study used DPPH, ABTS, and FRAP assays to evaluate antioxidant potential and XTT assay to assess cytotoxicity in human breast carcinoma cells.
Participant Demographics
MDA-MB-435S human breast carcinoma cells were used.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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