Circadian Rhythms and Metabolic Syndrome in Older Adults
Author Information
Author(s): Yue Yiwei, Rabinowitz Jill, An Yang, Kaizi-Lutu Marc, Liu Chunyu, Simonsick Eleanor, Schrack Jennifer, Spira Adam
Primary Institution: Johns Hopkins University
Hypothesis
How do circadian rhythm disturbances relate to metabolic syndrome in middle-aged and older adults?
Conclusion
Weaker and more phase-delayed circadian rhythms are linked to higher odds of metabolic syndrome in older adults.
Supporting Evidence
- 39 participants had metabolic syndrome at baseline.
- 24 participants developed metabolic syndrome over 4.5 years of follow-up.
- Higher relative amplitude was associated with 29% lower odds of metabolic syndrome.
- A later M10 time was linked to a faster increase in odds of developing metabolic syndrome.
Takeaway
If your body clock is out of sync, it might make you more likely to have health problems like diabetes and high blood pressure.
Methodology
Participants wore wrist actigraphy for about 6.6 nights to measure their circadian rhythms and were assessed for metabolic syndrome.
Limitations
The study is observational and may not establish causation.
Participant Demographics
Mean age 72.6 years, 20.6% Black adults, 54.1% women.
Statistical Information
P-Value
p=0.046 for RA, p=0.014 for M10 time
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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