MPO Polymorphism and Esophageal Cancer Risk
Author Information
Author(s): Matsuo Keitaro, Hamajima Nobuyuki, Shinoda Masayuki, Hatooka Shunzo, Inoue Manami, Takezaki Toshiro, Onda Hiroyuki, Tajima Kazuo
Primary Institution: Aichi Cancer Center Research Institute
Hypothesis
Does the MPO -463 G/A polymorphism reduce susceptibility to esophageal cancer?
Conclusion
The MPO -463 A allele may reduce the risk of esophageal cancer, particularly in older individuals who smoke.
Supporting Evidence
- The allele frequency for MPO -463A was 8.2% for cases and 10.5% for controls.
- The adjusted odds ratio for the GG/GA genotype was significantly low (0.15) for those aged 61 years or older.
- No difference was observed in disease risk when prevalent and incident cases were compared.
Takeaway
People with a specific gene variant might be less likely to get esophageal cancer, especially if they are older and smoke.
Methodology
A case-control study with 91 esophageal cancer patients and 241 non-cancer controls, examining MPO genotypes using PCR-RFLP.
Limitations
The study included prevalent cases and had partial statistical significance.
Participant Demographics
91 esophageal cancer patients (76 males, 15 females; median age 61) and 241 non-cancer controls (118 males, 123 females; median age 58).
Statistical Information
P-Value
0.022
Confidence Interval
0.03-0.76
Statistical Significance
p=0.022
Digital Object Identifier (DOI)
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