Dopamine Receptor Genes and Body Composition in Kenyan Pastoralists
Author Information
Author(s): Eisenberg Dan T A, Campbell Benjamin, Gray Peter B, Sorenson Michael D
Primary Institution: Department of Anthropology, Northwestern University
Hypothesis
How do genetic polymorphisms in dopamine receptors relate to body mass index and height among nomadic and settled Ariaal men?
Conclusion
The DRD4/7R allele may provide a selective advantage for nomadic Ariaal men, leading to better nutritional status compared to settled individuals.
Supporting Evidence
- DRD4/7R allele frequencies were 19.4% and 28.2% for DRD2/A1.
- BMI was higher in nomadic individuals with one or two DRD4/7R alleles.
- Height was unrelated to either DRD2 or DRD4 genotypes.
Takeaway
This study found that a specific gene variant helps nomadic men in Kenya stay healthier, while it has the opposite effect on those who have settled down.
Methodology
The study analyzed genetic polymorphisms in the DRD2 and DRD4 genes and their relationship with body mass index and height among two groups of Ariaal men.
Potential Biases
Potential biases may arise from the non-random selection of participants and the reliance on self-reported data.
Limitations
The sample sizes for some genotypes were small, which may limit the generalizability of the findings.
Participant Demographics
Participants included 87 recently settled and 65 nomadic Ariaal men from northern Kenya.
Statistical Information
P-Value
0.610 for allele frequency differences
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website