Prognostic value of vascular endothelial growth factor (VEGF) in head and neck squamous cell carcinomas
2000
The Role of VEGF in Head and Neck Cancer
Sample size: 60
publication
Evidence: high
Author Information
Author(s): Mineta H, Miura K, Ogino T, Takebayashi S, Misawa K, Ueda Y, Suzuki I, Dictor M, Borg Å, Wennerberg J
Primary Institution: Hamamatsu University School of Medicine
Hypothesis
The study examines the clinical significance of VEGF expression in head and neck squamous cell carcinomas.
Conclusion
High levels of VEGF expression are linked to poorer disease-free survival in head and neck cancer patients.
Supporting Evidence
- High VEGF expressors were found in 43% of patients.
- The 2-year disease-free survival rate was 30% for high VEGF expressors compared to 78% for low expressors.
- High VEGF expression correlated with poor disease-free survival.
Takeaway
This study found that patients with high VEGF levels in their tumors are more likely to have their cancer spread and have a lower chance of staying cancer-free.
Methodology
The study used Western blot, immunohistochemistry, and RT-PCR to analyze VEGF expression in tumor samples.
Statistical Information
P-Value
0.00007
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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