Improving Olmesartan Solubility with Cyclodextrin
Author Information
Author(s): Man Dana Emilia, Nițu Ema-Teodora, Temereancă Claudia, Sbârcea Laura, Ledeți Adriana, Ivan Denisa, Ridichie Amalia, Andor Minodora, Jîjie Alex-Robert, Barvinschi Paul, Rusu Gerlinde, Văruţ Renata-Maria, Abdelkader Hamdy, Al-Fatease Adel, Wu Zimei
Primary Institution: Victor Babeș University of Medicine and Pharmacy
Hypothesis
Can the inclusion complex of olmesartan medoxomil and heptakis(2,6-di-O-methyl)-β-cyclodextrin improve the drug's solubility and compatibility with excipients?
Conclusion
The study found that the olmesartan/cyclodextrin inclusion complex significantly enhances the solubility of olmesartan, but caution is needed when using certain excipients at high temperatures.
Supporting Evidence
- The inclusion complex showed a 1.83-fold increase in olmesartan solubility compared to the pure drug.
- Thermal analysis indicated compatibility with some excipients but potential incompatibility with magnesium stearate and α-lactose monohydrate at high temperatures.
- FTIR and PXRD results confirmed the lack of interaction between the inclusion complex and excipients at ambient temperature.
Takeaway
This study shows that mixing a medicine called olmesartan with a special sugar can help it dissolve better, but we need to be careful about what else we mix it with.
Methodology
The inclusion complex was characterized using various techniques including phase solubility analysis, UV spectroscopy, and thermal methods.
Limitations
The study primarily focuses on the compatibility of the inclusion complex with a limited number of excipients and does not explore all potential interactions.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website