ZEB1 and Neuronal Survival Pathway in Ischemia
Author Information
Author(s): Bui Thai, Sequeira Judith, Wen Tong Chun, Sola Augusto, Higashi Yujiro, Kondoh Hisato, Genetta Tom
Primary Institution: Emory University School of Medicine
Hypothesis
ZEB1 links p63 and p73 in a neuronal survival pathway that is rapidly induced in response to cortical ischemia.
Conclusion
ZEB1 induction is part of a protective response by neurons to ischemia, potentially mitigating neuronal damage.
Supporting Evidence
- ZEB1 protein levels increase significantly in response to ischemia.
- ZEB1 protects neurons from oxygen-glucose deprivation.
- ZEB1 induction is regulated by p63 in the context of ischemia.
- ZEB1 represses the pro-apoptotic p73 isoform during ischemic conditions.
- ZEB1's role in neuronal survival is conserved across species.
Takeaway
When brain cells are hurt by a lack of oxygen, a protein called ZEB1 helps them survive by stopping other proteins that cause cell death.
Methodology
The study used histological, tissue culture, and molecular biological methods to analyze the role of ZEB1 in neuronal survival during ischemia.
Limitations
The study primarily focuses on specific models of ischemia and may not fully represent all types of ischemic conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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