Effects of ABCA1 Polymorphisms on Apolipoprotein E Levels in Cerebrospinal Fluid
Author Information
Author(s): Wahrle Suzanne E, Shah Aarti R, Fagan Anne M, Smemo Scott, Kauwe John SK, Grupe Andrew, Hinrichs Anthony, Mayo Kevin, Jiang Hong, Thal Leon J, Goate Alison M, Holtzman David M
Primary Institution: Washington University, St. Louis, MO, USA
Hypothesis
Do polymorphisms in ABCA1 affect CSF apoE levels in humans?
Conclusion
CSF apoE levels vary widely between individuals but are stable within individuals over a two-week interval, and ABCA1 SNPs do not affect these levels.
Supporting Evidence
- Mean CSF apoE level was 9.09 μg/ml with a standard deviation of 2.70 μg/ml.
- CSF apoE levels were stable within individuals over a two-week interval.
- Average apoE levels increased with age by ~0.5 μg/ml per 10 years.
- No significant associations were found between CSF apoE levels and the ten ABCA1 SNPs.
- CSF apoE levels did not vary according to AD status, APOE genotype, gender, or race.
Takeaway
This study looked at how a protein related to Alzheimer's disease varies in people's brains and found that it changes a lot from person to person but stays the same for each person over time.
Methodology
Measured apoE in CSF from 168 subjects and genotyped for ten ABCA1 SNPs.
Limitations
The study may not account for all genetic variations affecting CSF apoE levels.
Participant Demographics
Subjects aged 43 to 91 years, cognitively normal or with mild AD.
Statistical Information
P-Value
p = 0.76
Confidence Interval
0.02 to 0.08
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website