Interaction Between Liver Metabolism and Gut Short-Chain Fatty Acids via Liver–Gut Axis Affects Body Weight in Lambs
2024

How Gut and Liver Interact to Affect Lamb Weight

Sample size: 100 publication 10 minutes Evidence: moderate

Author Information

Author(s): Wang Haibo, Zhan Jinshun, Zhao Shengguo, Jiang Haoyun, Jia Haobin, Pan Yue, Zhong Xiaojun, Huo Junhong

Primary Institution: Institute of Animal Husbandry and Veterinary, Jiangxi Academy of Agricultural Science, Nanchang, China

Hypothesis

Gut volatile fatty acids, microbiota, and metabolites interact within the enterohepatic cycle and may influence animal growth and development.

Conclusion

The study found that lambs with higher daily weight gains had significantly greater body and carcass weights, as well as higher levels of certain fatty acids and digestive enzymes compared to those with lower gains.

Supporting Evidence

  • HADG lambs had significantly higher body weight and carcass weight than LADG lambs.
  • Propanoic acid and butyric acid levels were significantly higher in HADG lambs.
  • Digestive enzymes like beta-glucosidase and xylanase were significantly higher in HADG lambs.
  • Jejunal microbiota showed no significant differences in diversity between HADG and LADG lambs.

Takeaway

This study shows that the way lambs digest food and the bacteria in their gut can affect how much they weigh as they grow.

Methodology

The study involved raising 100 male Hu lambs under controlled conditions and comparing the metabolic profiles and microbiota of lambs with the highest and lowest daily weight gains.

Participant Demographics

100 male Hu lambs of similar birth weight and age.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3390/ijms252413386

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