Urinary GADD45G Protein and IgA Nephropathy Progression
Author Information
Author(s): Lee Min-Jeong, Yim Hyunee, Park Ji Eun, Park Inwhee, Kim Heungsoo, Shin Gyu-Tae, Santos-Silva Alice, Coimbra Susana
Primary Institution: Ajou University School of Medicine
Hypothesis
Urinary GADD45G protein excretion is associated with the progression of IgA nephropathy.
Conclusion
Elevated urinary GADD45G levels are significantly associated with poor renal outcomes in patients with IgA nephropathy.
Supporting Evidence
- Urinary GADD45G showed significant positive correlations with serum creatinine slopes and urinary protein.
- The highest tertile group of urinary GADD45G had a significantly higher SCr-slope than the lowest tertile group.
- Univariate Cox regression analysis indicated that urinary GADD45G was significantly associated with deterioration of renal function.
- Kaplan–Meier test showed a significant difference in event-free survival for deterioration of renal function between the highest urinary GADD45G tertile group and other tertile groups.
- The area under the ROC curve indicated urinary GADD45G had a good performance in predicting renal outcome.
Takeaway
This study found that a protein called GADD45G in urine can help predict if kidney disease will get worse in people with a specific type of kidney problem called IgA nephropathy.
Methodology
Patients with IgA nephropathy were studied, measuring urinary GADD45G and protein levels, and correlating these with renal function over time.
Limitations
The complexity of measuring urinary GADD45G concentrations may limit its practical application in clinical settings.
Participant Demographics
The study included 45 patients, with a mean age of approximately 44 years, and 57.8% were male.
Statistical Information
P-Value
0.010
Confidence Interval
1.12–2.36
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website