Fast Homocoupling of Aryl Halides in Flow Systems
Author Information
Author(s): Nagaki Aiichiro, Uesugi Yuki, Tomida Yutaka, Yoshida Jun-ichi, Kirschning Andreas
Primary Institution: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
Hypothesis
Can the integration of lithiation and FeCl3 promoted homocoupling in a flow microreactor enhance the efficiency of biaryl synthesis?
Conclusion
The use of FeCl3 enables rapid oxidative homocoupling of aryllithiums, integrating it with the halogen–lithium exchange of aryl halides.
Supporting Evidence
- The integrated flow microreactor system allows for the rapid generation and reaction of unstable aryllithium intermediates.
- High yields of homocoupling products were achieved even at low temperatures.
- The method enhances the synthetic utility of aryllithium compounds.
Takeaway
This study shows that we can quickly make complex molecules using a special setup that combines two chemical reactions in one go.
Methodology
The study utilized a flow microreactor system to integrate the generation of aryllithiums and their subsequent homocoupling with FeCl3.
Digital Object Identifier (DOI)
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