The D-lactate enigma: exploring the inflammatory influence of D-lactate in cattle
Author Information
Author(s): Burgos Rafael Agustín, Manosalva Carolina, Alarcón Pablo, Navarro Max, Quiroga John, Morán Gabriel, Gallastegui Jan, Brauchi Sebastián, Carretta María Daniella
Primary Institution: Universidad Austral de Chile
Hypothesis
D-lactate participates in the modulation of inflammatory processes in cattle.
Conclusion
D-lactate may enhance glycolytic activity and induce an inflammatory response in cattle, particularly in conditions like ruminal acidosis.
Supporting Evidence
- D-lactic acidosis is linked to various inflammatory manifestations in cattle.
- Elevated levels of D-lactate can lead to neurotoxic effects.
- D-lactate can modulate the inflammatory response through different cells and mechanisms.
- Inflammatory conditions associated with lameness are observed during ruminal acidosis.
Takeaway
D-lactate is a substance in cattle that can make them sick by causing inflammation, especially when they eat too much grain.
Methodology
This is a review article synthesizing current knowledge on D-lactate's roles and metabolic pathways.
Limitations
The review highlights gaps in understanding the physiological and pathophysiological roles of D-lactate.
Digital Object Identifier (DOI)
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