Genetic Links to Kidney Function and Endocrine Traits
Author Information
Author(s): Hwang Shih-Jen, Yang Qiong, Meigs James B, Pearce Elizabeth N, Fox Caroline S
Primary Institution: National Heart Lung and Blood Institutes, Bethesda, MD, USA
Hypothesis
We tested for association between SNPs and measures of kidney function and endocrine traits.
Conclusion
Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set.
Supporting Evidence
- The top SNPs associated with GFR, cysC, UAE, and TSH were identified with significant p-values.
- Four SNPs in or near the CST3 gene were highly associated with cysC levels.
- Genetic factors play a role in the progression of renal disease.
Takeaway
This study looked at how genes might affect kidney function and hormone levels in people. They found some strong links between certain genes and these health traits.
Methodology
Participants were genotyped for the Affymetrix GeneChip Human Mapping 100K SNP set, and associations were evaluated using generalized estimating equations and family-based association tests.
Potential Biases
The study's focus on multivariable models may have led to missing important bivariate associations.
Limitations
Kidney function was assessed by a single serum creatinine measure, which may lead to misclassification, and the sample was not ethnically diverse.
Participant Demographics
Participants were from the Framingham Heart Study, with a median eGFR of 53.7 ml/min/1.73 m2 among those with CKD.
Statistical Information
P-Value
1.6*10-05
Digital Object Identifier (DOI)
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