Transmission of Antibiotic Resistant E. coli in Couples
Author Information
Author(s): Lietzau Susanne, Raum Elke, Baum Heike, Marre Reinhard, Brenner Hermann
Primary Institution: German Centre for Research on Ageing, Heidelberg, Germany
Hypothesis
Is conjugal transmission a significant factor in the spread of antibiotic-resistant E. coli among couples?
Conclusion
Conjugal transmission is likely a key factor in the spread of antibiotic-resistant E. coli in community settings.
Supporting Evidence
- Resistance prevalences for ampicillin were 15.7% in women and 19.4% in men.
- Partners carrying resistance were the main risk factor for colonization with resistant E. coli.
- Odds ratios for ampicillin and cotrimoxazole resistance were 6.9 and 3.3, respectively.
Takeaway
If one partner has antibiotic-resistant bacteria, the other partner is more likely to have them too, like sharing a cold.
Methodology
Stool samples from couples were analyzed for E. coli resistance to antibiotics.
Potential Biases
Self-reports of antibiotic intake could introduce recall bias.
Limitations
The study was conducted in 2002-2003, and self-reported antibiotic use may not be reliable.
Participant Demographics
Mean age of index persons was 35 years, and 98% were employed; 72% of spouses were housewives.
Statistical Information
P-Value
<.0001
Confidence Interval
3.1–15.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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