Proliferative Activity in Borrmann Type 4 Gastric Carcinoma
Author Information
Author(s): Y. Kakeji, Y. Maehara, Y. Adachi, H. Baba, M. Mori, M. Furusawa, K. Sugimachi
Primary Institution: National Kyushu Cancer Center, Fukuoka, Japan
Hypothesis
Can proliferative activity be used as a prognostic factor in Borrmann type 4 gastric carcinoma?
Conclusion
High proliferative activity in Borrmann type 4 gastric carcinoma is associated with increased lymph node metastasis and poorer survival rates.
Supporting Evidence
- Patients with high PCNA labelling had a higher incidence of lymphatic permeation and metastasis.
- Survival rates were less favorable for patients with high PCNA labelling.
- PCNA labelling percentage is an independent prognostic factor.
Takeaway
This study found that cancers that grow faster are more likely to spread and make patients less likely to survive.
Methodology
The study measured proliferative activity using PCNA and AgNOR staining in surgical samples from 181 patients.
Limitations
The study is limited to a specific type of gastric cancer and may not apply to other types.
Participant Demographics
181 Japanese patients with primary Borrmann type 4 gastric cancer.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
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