Trait responsiveness to verbal suggestions predicts nocebo responding: A meta‐analysis
2025

How Suggestibility Affects Nocebo Responses

Sample size: 10 publication 10 minutes Evidence: moderate

Author Information

Author(s): Madeline V. Stein, Monika Heller, Sarah Chapman, G. James Rubin, Devin B. Terhune

Primary Institution: King's College London

Hypothesis

Does trait responsiveness to verbal suggestions influence nocebo responding?

Conclusion

The study found that individuals who are more suggestible tend to experience stronger nocebo responses.

Supporting Evidence

  • Suggestibility is a significant predictor of nocebo responding.
  • Studies with higher methodological quality showed stronger correlations.
  • Self-report measures were commonly used, which may introduce bias.

Takeaway

Some people are more likely to feel bad after being told they might feel bad, and this study looked at why that happens.

Methodology

A meta-analysis of 10 studies examining the correlation between suggestibility and nocebo responses.

Potential Biases

Potential publication bias and variability in suggestibility measures may affect the results.

Limitations

The studies included had low methodological quality and relied heavily on self-report measures.

Participant Demographics

The studies included a mix of healthy volunteers and patients, with varying age and gender distributions.

Statistical Information

P-Value

0.013

Confidence Interval

[95% CI: .04, .38]

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1111/bjhp.12774

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