Mosaic Embryo Transfer and Pregnancy Outcomes
Author Information
Author(s): Hong You Mi, Kim Soo Hyun, Park Hee Jin, Ryu Hyun Mee, Cha Dong Hyun, Kim Moon Young, Han You Jung, Cavoretto Paolo Ivo
Primary Institution: CHA Gangnam Medical Center, CHA University School of Medicine
Hypothesis
Can mosaic embryos lead to healthy pregnancies and live births?
Conclusion
Mosaic embryos can develop into euploid healthy infants, providing a viable option for patients without euploid embryos.
Supporting Evidence
- 77 out of 88 mosaic embryos were successfully implanted.
- 67 pregnancies maintained beyond 11 weeks, yielding an ongoing pregnancy rate of 76.1%.
- Amniocentesis revealed only 2 abnormal findings unrelated to the PGT-A results.
- No congenital anomalies were detected in 16 postnatal cases.
- The average gestational age at birth was 38.4 weeks.
- The average birth weight was 3313 g.
- Prenatal ultrasounds showed no abnormalities in the first trimester.
- Two cases showed mild renal pelvis dilatation in the second trimester but resolved by birth.
Takeaway
This study shows that even embryos with some genetic issues can still lead to healthy babies, which is good news for parents who don't have perfect embryos.
Methodology
This retrospective study analyzed pregnancies from mosaic embryo transfers at CHA Gangnam Medical Center, reviewing medical records and outcomes.
Potential Biases
The study may not fully represent all outcomes due to the limited number of cases with postnatal data.
Limitations
Limited postnatal follow-up data and potential overestimation of implantation rates due to multiple embryo transfers.
Participant Demographics
Participants were primarily mothers over 35 years old undergoing IVF.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website