Tumour necrosis factor- α and transforming growth factor- β are significantly associated with better prognosis in non-small cell lung carcinoma: putative relation with BCL -2-mediated neovascularization
2000
Cytokines and Lung Cancer Prognosis
Sample size: 61
publication
Evidence: moderate
Author Information
Author(s): Boldrini L, Calcinai A, Samaritani E, Pistolesi F, Mussi A, Lucchi M, Angeletti C A, Basolo F, Fontanini G
Primary Institution: University of Pisa, Pisa, Italy
Hypothesis
The study investigates the association of TNF-α and TGF-β with prognosis in non-small cell lung carcinoma (NSCLC).
Conclusion
Higher levels of TNF-α and TGF-β are associated with better prognosis in NSCLC patients.
Supporting Evidence
- TNF-α mRNA was present in 55.74% of NSCLC cases.
- TGF-β mRNA was present in 45.9% of NSCLC cases.
- Patients without nodal metastasis showed a favorable prognosis (P = 0.02).
- Less advanced tumor stage was associated with better prognosis (P = 0.02).
- Positive TNF-α and TGF-β cancers had a favorable prognosis (P = 0.01 and P = 0.03).
- There was a significant direct association between TNF-α and bcl-2 (P = 0.05).
- An inverse association was found between TNF-α and microvessel count (P = 0.03).
- A significant inverse correlation was observed between bcl-2 expression and vascular count (P = 0.05).
Takeaway
This study found that certain proteins in lung cancer can help predict how well patients will do.
Methodology
RT-PCR was used to assess mRNA expression of TNF-α and TGF-β in NSCLC samples.
Statistical Information
P-Value
P = 0.01, P = 0.02, P = 0.03, P = 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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