Study of Complement Receptor in Schizophrenia Patients
Author Information
Author(s): Arakelyan Arsen, Zakharyan Roksana, Khoyetsyan Aren, Poghosyan David, Aroutiounian Rouben, Mrazek Frantisek, Petrek Martin, Boyajyan Anna
Primary Institution: Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia
Hypothesis
Is there a relationship between complement receptor type 1 expression and schizophrenia?
Conclusion
Schizophrenia is associated with increased CR1 expression and C1q-CIC levels.
Supporting Evidence
- CR1 expression levels for erythrocytes were significantly higher in patients compared to controls.
- The median level of C1q-CIC in the blood serum was significantly higher in patients compared to controls.
- No significant difference was observed in the levels of C3d-CIC between groups.
Takeaway
This study found that people with schizophrenia have more of a certain protein on their blood cells, which might be linked to their condition.
Methodology
The study involved flow cytometry to measure CR1 expression on blood cells and ELISA to measure circulating immune complexes.
Limitations
The sample size was relatively small and all patients were receiving antipsychotic treatment.
Participant Demographics
117 schizophrenia patients (60 females, 57 males) and 142 healthy controls (70 females, 72 males), all unrelated Armenians.
Statistical Information
P-Value
p = 7.48E-07
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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