CCL3L Copy Number Variation and Simian-AIDS Progression in Rhesus Macaques
Author Information
Author(s): Gornalusse German, Mummidi Srinivas, He Weijing, Silvestri Guido, Bamshad Mike, Ahuja Sunil K.
Primary Institution: University of Texas Health Science Center, San Antonio, Texas, United States of America
Hypothesis
Does a low copy number of CCL3L genes affect the rate of progression to AIDS in macaques challenged with SIV?
Conclusion
Macaques with a low copy number of CCL3L genes experience a significantly faster rate of progression to AIDS.
Supporting Evidence
- Low CCL3L copy number is associated with faster progression to AIDS.
- CCL3L CNV accounts for ∼18% of variability in AIDS progression rates.
- Indian rhesus macaques progress more quickly to AIDS than Chinese macaques.
- Population structure was controlled using microsatellites.
Takeaway
Some monkeys have fewer copies of a gene that helps fight off a virus, and those monkeys get sick faster.
Methodology
The study used real-time PCR to analyze CCL3L gene copy numbers in macaques challenged with SIV.
Potential Biases
Population structure differences between Indian and Chinese macaques could confound results.
Limitations
The study may not account for all genetic and environmental factors influencing AIDS progression.
Participant Demographics
The study involved Indian and Chinese rhesus macaques.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website