New Carbazole Alkaloids with Anti-Ferroptotic Activity from Murraya euchrestifolia
Author Information
Author(s): Chen Yue-Mei, Cao Nan-Kai, Zhu Si-Si, Ding Meng, Liang Hai-Zhen, Zhao Ming-Bo, Zeng Ke-Wu, Tu Peng-Fei, Jiang Yong
Primary Institution: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191 People’s Republic of China
Hypothesis
The study investigates the isolation and characterization of novel carbazole alkaloids from Murraya euchrestifolia and their biological activities.
Conclusion
Fifteen novel carbazole alkaloids were identified, with significant anti-ferroptotic activity and potential for neuroprotection.
Supporting Evidence
- Compounds exhibited significant anti-ferroptotic activity with EC50 values ranging from 0.04 to 1 μM.
- Some compounds showed strong inhibition of nitric oxide production in RAW 264.7 cells.
- Compounds 4a, 4b, 6, and 11–14 had IC50 values below 20 μM for NO inhibition.
- Compounds 1, 5a, 5b, 8–10, and 15 showed moderate inhibitory activity with IC50 values between 21.6 to 32.5 μM.
- Compounds 4a, 5a, 5b, 6, and 8 exhibited considerable cytotoxic effects on HepG2 cells.
Takeaway
Scientists found 15 new compounds in a plant that can help protect brain cells from damage.
Methodology
The study involved the extraction of compounds from the plant, followed by structural elucidation using spectroscopic methods and evaluation of biological activities.
Digital Object Identifier (DOI)
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