Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patients
2001
MMP-9 as a Prognostic Indicator in Breast Cancer
Sample size: 210
publication
Evidence: moderate
Author Information
Author(s): Scorilas A, Karameris A, Arnogiannaki N, Ardavanis A, Bassilopoulos P, Trangas T, Talieri M
Primary Institution: ‘G.Papanikolaou’, Research Center of Oncology
Hypothesis
Is MMP-9 expression a favorable prognostic factor in node-negative breast cancer patients?
Conclusion
MMP-9 may serve as an independent favorable prognostic factor in node-negative breast cancer patients.
Supporting Evidence
- MMP-9 expression was primarily observed in cancer cells.
- MMP-9 levels below the cut-off were more frequent in larger tumors.
- MMP-9 was associated with a reduction in risk for relapse and death in node-negative patients.
Takeaway
This study found that a protein called MMP-9 can help doctors understand how likely it is for some breast cancer patients to get better.
Methodology
Immunoperoxidase staining was used to evaluate MMP-9 expression in breast cancer tissues.
Participant Demographics
Patients aged 45–55 years with node-negative breast cancer.
Statistical Information
P-Value
P = 0.009
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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