NFI-Regulome Database: A Tool for Gene Regulation Analysis
Author Information
Author(s): Richard M Gronostajski, Joseph Guaneri, Dong Hyun Lee, Steven M Gallo
Primary Institution: State University of New York at Buffalo
Conclusion
The NFI-Regulome database facilitates the rapid display and analysis of transcription factor binding sites in genes regulated by NFI transcription factors.
Supporting Evidence
- The database allows for easy annotation of regulatory regions of genes.
- It provides a platform for comparing gene expression patterns and regulatory structures.
- The majority of binding sites in the database are experimentally confirmed.
Takeaway
The NFI-Regulome database helps scientists understand how certain genes are controlled by specific proteins, which is important for studying diseases and development.
Methodology
The database was constructed using MySQL and includes annotations of binding sites for NFI transcription factors based on literature.
Limitations
The database currently focuses only on NFI transcription factors and relies on manual annotation from literature, which can be labor-intensive.
Digital Object Identifier (DOI)
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