Transient Hypothyroidism in a Newborn After Maternal Vinblastine Exposure
Author Information
Author(s): Amin Zubair, Aung Win Thu, Ng Yvonne Peng Mei
Primary Institution: Khoo Teck Puat-National University Children Medical Institute, National University Health System, Singapore
Hypothesis
Can maternal exposure to vinblastine during pregnancy lead to transient congenital hypothyroidism in the newborn?
Conclusion
This case suggests that maternal exposure to vinblastine during pregnancy may be associated with transient congenital hypothyroidism in the newborn.
Supporting Evidence
- The mother received two cycles of vinblastine during her third trimester.
- The baby was treated with thyroxine for 18 months and showed normal growth and development.
- Thyroid function tests indicated congenital hypothyroidism in the newborn.
Takeaway
A baby can have thyroid problems if their mom took a certain cancer medicine while pregnant, but with the right treatment, the baby can grow up healthy.
Methodology
The case was reported following the CARE guidelines.
Limitations
The study highlights an association without establishing direct causation, and maternal and infant vinblastine levels were not assessed.
Participant Demographics
The mother is a 30-year-old previously healthy Malay woman.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website