Clostridium perfringens Delta Toxin Is Sequence Related to Beta Toxin, NetB, and Staphylococcus Pore-Forming Toxins, but Shows Functional Differences
2008
Clostridium perfringens Delta Toxin and Its Functional Differences
publication
Evidence: moderate
Author Information
Author(s): Manich Maria, Knapp Oliver, Gibert Maryse, Maier Elke, Jolivet-Reynaud Colette, Geny Blandine, Benz Roland, Popoff Michel R.
Primary Institution: Institut Pasteur, Paris, France
Hypothesis
How does the Delta toxin from Clostridium perfringens differ functionally from other related toxins?
Conclusion
Delta toxin shows significant sequence homology with other toxins but exhibits different channel properties in lipid bilayers.
Supporting Evidence
- Delta toxin is cytotoxic for cells expressing the ganglioside GM2.
- Delta toxin forms slightly anion-selective channels in lipid bilayers.
- Delta toxin shows a significant sequence homology with C. perfringens Beta toxin and NetB.
Takeaway
Delta toxin from Clostridium perfringens can make holes in cell membranes, which is important for understanding how it causes disease.
Methodology
The study involved genetic characterization and pore-forming activity analysis of Delta toxin in lipid bilayers.
Digital Object Identifier (DOI)
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