Coagulation Tests in Diabetic Patients in Africa
Author Information
Author(s): Getu Fasil, Alemayehu Ermiyas, Tesfaye Addisu, Genanew Birhanu, Walle Muluken
Primary Institution: Jigjiga University
Hypothesis
What is the pooled Standard Mean Difference (SMD) of prothrombin time (PT) and activated partial thromboplastin time (APTT) among diabetic patients in Africa compared to healthy controls?
Conclusion
This study found no statistically significant difference in prothrombin time and activated partial thromboplastin time between diabetic patients and healthy controls in Africa.
Supporting Evidence
- The pooled SMD of PT among DM patients in Africa was −0.18.
- The pooled SMD of APTT among DM patients in Africa was −0.48.
- Type 1 DM patients showed a statistically significant difference in APTT compared to Type 2 DM patients.
- High heterogeneity was observed in the included studies.
- Subgroup analyses revealed no significant differences in PT and APTT across different regions in Africa.
Takeaway
Doctors checked blood clotting times in diabetes patients in Africa and found that diabetes doesn't change these times much compared to healthy people.
Methodology
This systematic review and meta-analysis followed PRISMA guidelines, included studies from various databases, and used random-effect models for analysis.
Potential Biases
High level of heterogeneity was observed in the analyses.
Limitations
The study is limited by the inclusion of only English-language studies and the observational nature of the included studies.
Participant Demographics
Participants included various racial and ethnic groups from different African countries.
Statistical Information
P-Value
p=0.041 for Type 1 DM APTT
Confidence Interval
95% CI: −0.72, 0.36 for PT; 95% CI: −1.18, 0.21 for APTT
Statistical Significance
p=0.514 for PT, p=0.174 for APTT
Digital Object Identifier (DOI)
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