Clinical Manifestations Associated with Neurocysticercosis: A Systematic Review
Author Information
Author(s): Carabin Hélène, Ndimubanzi Patrick Cyaga, Budke Christine M., Nguyen Hai, Qian Yingjun, Cowan Linda Demetry, Stoner Julie Ann, Rainwater Elizabeth, Dickey Mary
Primary Institution: University of Oklahoma Health Sciences Center
Hypothesis
This systematic review aims to estimate the frequencies of different manifestations, complications and disabilities associated with neurocysticercosis (NCC).
Conclusion
NCC is a pleomorphic disease linked to a range of manifestations, with seizures/epilepsy being the most common.
Supporting Evidence
- Among patients seen in neurology clinics, seizures/epilepsy were the most common manifestations (78.8%).
- Headaches occurred in 37.9% of patients.
- Focal deficits were reported in 16.0% of patients.
- Signs of increased intracranial pressure were found in 11.7% of patients.
Takeaway
Neurocysticercosis can cause many different symptoms, but most people with it have seizures or headaches.
Methodology
A systematic search of the literature published from January 1, 1990, to June 1, 2008, was conducted, and meta-analyses were performed when appropriate.
Potential Biases
The study may have selection bias as it only included symptomatic patients from neurology clinics.
Limitations
The estimates are only applicable to patients who are ill enough to seek care in neurology clinics and likely overestimate the frequency of manifestations among all NCC cases.
Participant Demographics
Patients included were from various countries and age groups, primarily those seeking care in neurology clinics.
Statistical Information
Confidence Interval
95% CI: 65.1%–89.7%
Digital Object Identifier (DOI)
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