Effects of Crystalloid Fluids on Heart Function in Severe Sepsis
Author Information
Author(s): Fang Zhi Xun, Li Yu Feng, Zhou Xiao Qing, Zhang Zhen, Zhang Jin Song, Xia Hai Ming, Xing Guo Ping, Shu Wei Ping, Shen Ling, Yin Guo Qing
Primary Institution: The Second Hospital of Nanjing, affiliated with Medical School, Southeast University
Hypothesis
The study investigates the effects of three different crystalloid solutions on fluid resuscitation in patients with severe sepsis and hypotension.
Conclusion
All three crystalloid solutions may be used for initial volume loading in severe sepsis, and sodium bicarbonate confers a limited benefit on humans with severe sepsis.
Supporting Evidence
- Sodium bicarbonate improved mean arterial pressure and cardiac output more quickly than normal saline or hypertonic sodium chloride.
- There were no significant differences in mortality rates among the three groups after 28 days.
- Fluid resuscitation did not alter heart or respiratory rates in any group during the trial.
Takeaway
Doctors tested three types of fluids to help very sick patients with low blood pressure, and found that all three worked, but one type helped a little faster.
Methodology
Ninety-four severe sepsis patients were randomly assigned to three groups receiving different crystalloid solutions, and various physiological parameters were measured.
Potential Biases
Potential bias due to the long duration of the study and the exclusion of patients with certain conditions.
Limitations
The groups were heterogeneous in age and lactic acid levels, and the study did not use invasive techniques to measure certain hemodynamic parameters.
Participant Demographics
Patients had a mean age of 44.19 years in the normal saline group, 49.17 years in the hypertonic saline group, and 32.59 years in the sodium bicarbonate group.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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