Omentin-1 and Bone Health in Multiple Sclerosis
Author Information
Author(s): Assadi Majid, Salimipour Hooman, Akbarzadeh Samad, Nemati Reza, Jafari Syed Mojtaba, Bargahi Afshar, Samani Zahra, Seyedabadi Mohammad, Sanjdideh Zahra, Nabipour Iraj
Primary Institution: Bushehr University of Medical Sciences, Bushehr, Iran
Hypothesis
Are circulating levels of omentin-1 and vaspin related to bone health in multiple sclerosis patients?
Conclusion
Elevated omentin-1 serum levels are correlated with bone mineral density at the femoral neck and serum levels of osteocalcin and osteopontin in multiple sclerosis patients.
Supporting Evidence
- Omentin-1 levels were positively correlated with BMD at the femoral neck.
- No significant differences in bone-related cytokines between MS patients and healthy controls.
- The study included a total of 73 participants.
Takeaway
This study found that a substance called omentin-1 in the blood is linked to better bone health in people with multiple sclerosis.
Methodology
The study compared 35 MS patients with 38 healthy controls, measuring bone mineral density and various serum levels using specific assays.
Potential Biases
Potential bias due to the cross-sectional design and single measurements of adipocytokines.
Limitations
The sample size was small and the study only included ambulatory MS patients, limiting generalizability.
Participant Demographics
35 MS patients (mean age 31.57 years, 27 women, 8 men) and 38 age- and sex-matched healthy controls (mean age 30.0 years, 30 women, 8 men).
Statistical Information
P-Value
p=0.016 for omentin-1 correlation with BMD at femoral neck
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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