Epidermal Growth Factor Receptor Expression in Human Foetal Tissues
Author Information
Author(s): A.M. Oliver
Primary Institution: Department of Pathology, University Medical Buildings, Foresterhill, Aberdeen, UK
Hypothesis
The study aims to characterize EGFr expression in various foetal tissues to determine their suitability for further study on the role of EGFr in oncogenesis.
Conclusion
EGFr gene expression is significant in foetal tissues at around 17 weeks estimated gestational age.
Supporting Evidence
- EGFr was detected in the majority of foetal tissues studied at 17 weeks EGA and above.
- Prior to 17 weeks EGA, EGFr was not expressed except in certain tissues where weak staining was observed at 16 weeks.
- By 18 weeks EGA, intense staining for EGFr was observed on all tissues studied.
Takeaway
This study looked at how a specific protein, EGFr, is found in different parts of a baby before birth, and it found that this protein starts showing up around 17 weeks.
Methodology
Fresh tissue samples were obtained from normal foetuses, and EGFr was identified using immunohistochemical methods.
Limitations
The study only examined foetal tissues and did not explore the role of other receptors before 16-17 weeks EGA.
Participant Demographics
Foetal tissues from 14-19 weeks estimated gestational age.
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