Identifying Genes Linked to Arthritis in Mice
Author Information
Author(s): Liljander Maria, Sällström Mary-Ann, Andersson Sara, Andersson Åsa, Holmdahl Rikard, Mattsson Ragnar
Primary Institution: Lund University
Hypothesis
Can we identify genetic regions that control collagen-induced arthritis in aged female mice?
Conclusion
The study found that multiparity does not negatively influence the incidence or severity of collagen-induced arthritis in aged female mice, and identified new genetic loci associated with the disease.
Supporting Evidence
- The study identified a significant quantitative trait locus on chromosome 11 associated with arthritis incidence.
- Multiparity did not significantly affect the incidence or severity of collagen-induced arthritis in the studied mice.
- A suggestive locus was found on chromosome 1 associated with disease traits.
- Another suggestive locus was identified on chromosome 13 related to anti-CII antibody titers.
Takeaway
This study looked at female mice to see if having babies affected their chances of getting arthritis. It found that having babies didn't make a difference, and it also found new genes that might be linked to arthritis.
Methodology
The study used a total genome-wide screening with 125 microsatellite markers on 200 female mice to identify genetic loci associated with collagen-induced arthritis.
Limitations
The study focused only on female mice and may not be generalizable to males or other species.
Participant Demographics
Aged multiparous female mice of a cross between NFR/N and B10.Q strains.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website