Identifying Responders to Hypertension Treatment
Author Information
Author(s): Schmieder Roland E., Hettrick Douglas A., Böhm Michael, Kandzari David E., Kario Kazuomi, Mahfoud Felix, Tsioufis Konstantinos, Weber Michael A., Esler Murray D., Townsend Raymond R.
Primary Institution: University Hospital Erlangen, Erlangen, Germany
Hypothesis
Can we better define responders to renal denervation treatment in hypertension?
Conclusion
A more accurate definition of responders to hypertension treatments should consider multiple factors, including blood pressure variability and baseline levels.
Supporting Evidence
- Multiple clinical trials show significant blood pressure reductions after renal denervation.
- Visit-to-visit blood pressure variability complicates the identification of true responders.
- Current responder definitions may not account for the temporal response to treatment.
Takeaway
This study looks at how to tell if patients will benefit from a specific blood pressure treatment, suggesting we need to consider more than just one measurement.
Methodology
The review analyzes data from recent clinical trials and discusses the limitations of current responder definitions.
Potential Biases
Potential biases may arise from relying on single-point measurements for defining treatment responses.
Limitations
Current definitions of responders may not accurately reflect individual patient responses due to visit-to-visit blood pressure variability.
Participant Demographics
Patients with uncontrolled hypertension, including those not randomized in the SPYRAL HTN-ON MED trial.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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