Predicting Treatment Responses in Kidney Sarcoidosis
Author Information
Author(s): DİRİM Ahmet Burak, SÜLEYMANOVA Vafa, HÜRDOĞAN Özge, OTO Özgür Akın, ARTAN Ayşe Serra, ÖZTÜRK Savaş, ÖZLÜK Yasemin, KILIÇASLAN Işın, YAZICI Halil
Primary Institution: İstanbul University, İstanbul, Turkiye
Hypothesis
The study investigates the clinical, pathological, and laboratory findings that predict treatment responses in patients with kidney sarcoidosis treated with immunosuppressives.
Conclusion
Hypercalcemia and lower interstitial fibrosis and tubular atrophy rates might be associated with better outcomes in sarcoidosis-related kidney involvement under immunosuppressive treatment.
Supporting Evidence
- Nineteen of the 23 patients were diagnosed with nonglomerular disease.
- Granulomatous interstitial nephritis was the most common diagnosis at 56.5%.
- Steroids improved the eGFR in the first month compared to baseline in patients with nonglomerular diseases.
- 45% of the patients developed end-stage kidney disease during follow-up.
- Patients with higher baseline calcium levels had better kidney outcomes.
Takeaway
This study looked at patients with kidney problems caused by sarcoidosis and found that those with high calcium levels and less kidney damage did better with treatment.
Methodology
A retrospective study evaluating demographic, clinical, pathological, and laboratory findings of 23 patients with biopsy-confirmed kidney sarcoidosis.
Potential Biases
Potential bias due to incomplete follow-up data and reliance on electronic healthcare records.
Limitations
The study's retrospective nature and lack of regular follow-up data may limit the findings.
Participant Demographics
Median age was 47 years, with 60.9% female participants.
Statistical Information
P-Value
p = 0.03 for calcium levels; p = 0.043 for interstitial fibrosis/tubular atrophy.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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