The relationship of body weight to response to endocrine therapy, steroid hormone receptors and survival of patients with advanced cancer of the breast
1989
Body Weight and Breast Cancer Response
Commentary
Author Information
Author(s): V. Hug
Primary Institution: University of Texas, MD Anderson Cancer Center
Hypothesis
Does body weight influence the response to endocrine treatment and survival in breast cancer patients?
Conclusion
The author argues that body weight does influence the length of disease-free survival and response to endocrine treatment in hormone-responsive breast cancer patients.
Supporting Evidence
- Body weight influences the size and oestrogen receptor status of breast tumors.
- Only one-third of breast tumors are clinically oestrogen-sensitive.
- An oestrogen-rich microenvironment can increase the oestrogen sensitivity of hormone-dependent tumors.
Takeaway
The author believes that body weight can affect how well breast cancer patients respond to treatment, especially for those whose tumors are sensitive to hormones.
Limitations
The commentary does not provide specific data or a detailed methodology for the author's own studies.
Participant Demographics
Patients with hormone-responsive tumors.
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