Identification of a Novel Intracellular Interaction Domain Essential for Bves Function
2008
Understanding Bves Function in Cell Adhesion
publication
Evidence: high
Author Information
Author(s): Kawaguchi Michiya, Hager Hillary A., Wada Aya, Koyama Tatsuki, Chang Min S., Bader David M.
Primary Institution: Vanderbilt University
Hypothesis
Bves has an intracellular interaction domain essential for its function in cell adhesion.
Conclusion
The study identifies a specific domain in Bves that is crucial for maintaining cell adhesion and epithelial integrity.
Supporting Evidence
- Bves interacts with itself through an intracellular domain essential for adhesion.
- Mutations in specific amino acids disrupt cell adhesion and junction formation.
- Expression of mutated Bves leads to a mesenchymal phenotype in epithelial cells.
Takeaway
Bves is a protein that helps cells stick together, and this study found a part of it that is really important for that job.
Methodology
The study used transfection of Bves constructs in cell lines and various assays to assess cell adhesion and electrical resistance.
Statistical Information
P-Value
<0.0001
Confidence Interval
(0.07, 0.14)
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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