The Role of CD276 in Cancer Progression
Author Information
Author(s): Liu Lilong, Yao Zhipeng, Liu Yiting, Li Yang, Ding Yuhong, Hu Junyi, Liu Zhenghao, Shi Pengjie, Chen Ke, Liu Zheng, Zhang Wenhao, Hou Yaxin, Jeltsch Albert, Suzuki Yutaka
Primary Institution: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Hypothesis
This study aims to perform a pan-cancer analysis of the oncogenic role of CD276 in human tumors.
Conclusion
CD276 might promote tumor progression by creating an immunosuppressive microenvironment.
Supporting Evidence
- CD276 was found to be a potential biomarker for the prognosis of most cancers.
- High expression of CD276 was associated with tumor progression and poor survival.
- Up-regulation of CD276 expression increased tumor infiltration of cancer-associated fibroblasts and myeloid-derived suppressor cells while decreasing CD8+ T cells.
Takeaway
CD276 is a protein that helps tumors grow by making the environment around them less friendly to the immune system, which normally fights cancer.
Methodology
The study used various databases to analyze CD276 expression levels, its relationship with tumor progression, patient survival, immune cell infiltration, and associated signaling pathways.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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